Sigma Receptor
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Sigma Receptor Verwandte Produkte (108)
Verwandte Produkte (108)
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CM572
0 ImagesArt. -Nr.: HY-122112CAS. Nr.: 1121932-91-9CM572 is a selective irreversible partial sigma-2 receptor agonist. CM572 has antitumor activity. CM572 induces dose-dependent cell death, with an EC50 of 7.6 μM in SK-N-SH neuroblastoma cells. CM572 can be used for the research of kinds of diseases such as neuroblastoma, breast cancer.
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PRE-084
0 ImagesArt. -Nr.: HY-18100CAS. Nr.: 138847-85-5PRE-084 is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
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N-Desmethyl xanomeline
0 ImagesArt. -Nr.: HY-181425CAS. Nr.: 131986-96-4N-Desmethyl xanomeline is a pharmacologically active metabolite of Xanomeline (HY-105182). N-Desmethyl xanomeline binds to muscarinic, serotonergic, histaminergic and dopaminergic receptors. N-Desmethyl xanomeline can be used for the research of schizophrenia.
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Rimcazole dihydrochloride (Standard)
0 ImagesArt. -Nr.: HY-108510RCAS. Nr.: 75859-03-9Synonyms: BW 234U dihydrochloride (Standard)Rimcazole dihydrochloride (Standard) is the analytical standard of Rimcazole (dihydrochloride) (HY-108510). This product is intended for research and analytical applications. Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.
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Sigma-2 Receptor ligand 2
0 ImagesArt. -Nr.: HY-184175CAS. Nr.: 1816276-88-6Sigma-2 Receptor ligand 2 is a fluorescence labeled sigma-2 ligand. Sigma-2 Receptor ligand 2 can be used as a fluorescent probe.
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(±)-PPCC
0 ImagesArt. -Nr.: HY-111081CAS. Nr.: 932736-90-8(±)-PPCC is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±)-PPCC has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats.
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Blarcamesine hydrochloride (Standard)
0 ImagesArt. -Nr.: HY-101864RCAS. Nr.: 195615-84-0Synonyms: Anavex 2-73 (Standard)Blarcamesine hydrochloride (Standard) is the analytical standard of Blarcamesine hydrochloride (HY-101864). This product is intended for research and analytical applications. Blarcamesine hydrochloride (Anavex 2-73) is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
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BD-1047 dihydrobromide (Standard)
0 ImagesBD-1047 (dihydrobromide) (Standard) is the analytical standard of BD-1047 (dihydrobromide). This product is intended for research and analytical applications. BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors. BD-1047 dihydrobromide attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches.
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Opipramol-d4
0 ImagesArt. -Nr.: HY-118901SCAS. Nr.: 1215716-70-3Synonyms: Ensidon-d4; G-33040-d4Opipramol-d4 is the deuterium labeled Opipramol.
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Zervimesine (Standard)
0 ImagesArt. -Nr.: HY-111669RCAS. Nr.: 1802632-22-9Synonyms: CT1812 (Standard); Sigma-2 receptor antagonist 1 (Standard)Zervimesine (Standard) is the analytical standard of Zervimesine (HY-111669). This product is intended for research and analytical applications. Zervimesine (CT1812) is an orally active and brain penetrant sigma-2 receptor antagonist with a Ki of 8.5 nM. Zervimesine can be used for the research of Alzheimer’s disease.
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4-IBP (Standard)
0 Images4-IBP (Standard) is the analytical standard of 4-IBP (HY-100155). This product is intended for research and analytical applications. 4-IBP is a selective σ₁ receptor agonist with high affinity for the σ₁ receptor (Ki =1.7 nM) and moderate affinity for the σ₂ receptor (Ki = 25.2 nM). 4-IBP can make cancer cells more sensitive to the cytotoxic effects of pro-apoptotic and pro-autophagic compounds. 4-IBP significantly reduces the migration ability of a variety of cancer cells. 4-IBP is mainly used in glioblastoma, non-small cell lung cancer and prostate cancer research.
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Thiothixene
0 ImagesThiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.
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Blarcamesine (Standard)
0 ImagesBlarcamesine (Standard) is the analytical standard of Blarcamesine (HY-105296). This product is intended for research and analytical applications. Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.
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BMY-14802 hydrochloride (Standard)
0 ImagesArt. -Nr.: HY-108509RCAS. Nr.: 105565-55-7Synonyms: BMY-14802-1 (Standard); BMS 181100 hydrochloride (Standard)BMY-14802 hydrochloride (Standard) is the analytical standard of BMY-14802 (hydrochloride) (HY-108509). This product is intended for research and analytical applications. BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.
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Chlophedianol hydrochloride (Standard)
0 ImagesArt. -Nr.: HY-A0161ARCAS. Nr.: 511-13-7Synonyms: Clofedanol hydrochloride (Standard); Calmotusin hydrochloride (Standard); NSC 113595 hydrochloride (Standard)Chlophedianol (hydrochloride) (Standard) is the analytical standard of Chlophedianol (hydrochloride). This product is intended for research and analytical applications. Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs).
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Pentoxyverine (Standard)
0 ImagesSynonyms: Carbetapentane (Standard)Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.
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NE-100 hydrochloride (Standard)
0 ImagesArt. -Nr.: HY-101484ARCAS. Nr.: 149409-57-4NE-100 hydrochloride (Standard) is the analytical standard of NE-100 hydrochloride (HY-101484A). This product is intended for research and analytical applications. NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases.
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Glycerol phenylbutyrate (Standard)
0 ImagesArt. -Nr.: HY-B2087RCAS. Nr.: 611168-24-2Synonyms: HPN-100 (Standard)Glycerol phenylbutyrate (Standard) is the analytical standard of Glycerol phenylbutyrate. This product is intended for research and analytical applications. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger agent.
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PB28 dihydrochloride (Standard)
0 ImagesArt. -Nr.: HY-108511RCAS. Nr.: 172907-03-8PB28 dihydrochloride (Standard) is the analytical standard of PB28 (dihydrochloride) (HY-108511). This product is intended for research and analytical applications. PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a Ki of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity.
